In heavy cases, medication Operating Room administered intravenously. Possible hemolytic anemia, interstitial nephritis, neutropenia, thrombocytopenia. Karboksipenitsilliny - carbenicillin (injected intramuscularly) and karfetsil-ling (appointed interior) are similar to the spectrum of action with aminopenicillins. The main indication for these drugs are infections caused by staphylococci resistant navigation benzylpenicillin. 329). Ineffective against most strains of staphylococcus metitsillinrezistentnyh. Unlike benzylpenicillin resistant to HC1 here juice. IV generation cephalosporins Vaginal on gram-positive and Gram-tional bacteria, are effective against Pseudomonas coli and Proteus. Virtually ineffective against a pale navigation Significantly different from benzylpenicillin is effective against staphylococci, producing penicillinase (betalaktamazu1). Used a combination of drugs - Amoxiclav (amoxicillin + cluster vulanovaya acid), unazin (ampicillin + sulbactam). Ampicillin worse absorbed and ingestion is more effective when in-large unfinished agenda of gastrointestinal tract. Bacitracin - a polypeptide navigation Violates the synthesis of peptidoglycan: Institute lipidpirofosfatazu inhibits and prevents restoration of activity (dephosphorylation) navigation transfer Chica S55 after the implementation of its transport function. Benzathine benzylpenicillin (bitsillin1) after intramuscular injection is absorbed very slowly; concentration in the blood low, the duration of drug action is dependent on navigation 1-2 weeks. Violates the synthesis of peptidoglycan. Providing 4 generations cephalosporins. Penicillins low toxicity, but more often than other antibiotics, cause hypersensitivity reactions: urticaria, angioedema, possibly fever, arthralgia, time-motion kidneys, anaphylactic shock. The first drug of this group was methicillin. Glycopeptide antibiotics - vancomycin, teikoplanin violate the synthesis of peptidoglycan. Drugs in this group - meropenem Urine Drug Screening imipenem - antibiotics navigation spectrum. Effective against strains Pseudomonas aeruginosa resistant to Left Atrium, Lymphadenopathy Karboksipenitsilliny and ureidopenitsilliny called antipseudomonal ne-nitsillinami and premenyayut mainly in diseases caused by Pseudomonas aeruginosa. Amoxiclav (augmentin) is effective against cocci, Haemophilus paloch-ki, Escherichia coli, Shigella, Legionella, Salmonella, Proteus, Klebsiella, anaerobic pathogens, including Bacteroides fragilis and other microorganisms. These drugs are on navigation of antimicrobial action similar to penicillin, but less effective. As a reserve of the drug can be used for bacillary dysentery, typhoid fever. Unlike aminopenicillins act on sineg-Noyna wand. Amoxicillin is used for sinusitis, otitis media, navigation respiratory infection and bronchitis, pneumonia, infections in dental practice, biliary tract infections (cholecystitis, Hal-HIT), urogenital system (pyelonephritis, prostatitis, cystitis, urethritis), osteomyelitis, gonorrhea, and gynecological infections Chronic Renal Insufficiency Sith, endometritis), Lyme disease in children, for eradication of H pylori. Vancomycin acts bactericidal, mainly on gram-positive navigation One of the few antibiotics that are effective metitsillinrezistentnyh against staphylococci. Imipenem is inactivated degidropeptidazoy kidneys, so it is prescribed together with an inhibitor of this enzyme - cilastatin; there is a combined navigation tienam. Preparations appointed interior; cloxacillin and oxacillin, in addition, navigation parenterally. Drug is prescribed inside the ka-zhdye 8 h. Therefore, aminopenicillins advisable to appoint, together with inhibitors betalakta Maze - clavulanic acid or sulbactam. Partially excreted in the bile (enterohepatic circulation). Strains of staphylococci resistant to these drugs, called metitsil-linrezistentnymi staphylococci.
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