Pharmaceutical Engineering Guides (ISPE) and Inclusion Body

Side effects and complications in the use of drugs: nausea, hyperemia, easy fatigue, skin rash, itching, bruising, sweating, chills, tremors, fever, leg pain, cold limbs, feeling the heat, dryness and irritation of the throat, ear inflammatory disease and lower hearing, AR - urticaria, rash, Dyspnoe, cough, chest pain, lower blood pressure, anaphylaxis, in people with hemophilia A - the formation of neutralizing a / t, inhibitors black leg Factor VIII (the risk of complications is highest during the first 20 days of a drug ). Side effects and complications in the use of drugs: hypersensitivity or AR up to development of allergic shock, in patients with hemophilia A may be a / t (inhibitors) to factor VIII, which revealed the absence of clinical hemostatic effect in response of therapy and after application black leg doses in patients with Tricuspid Stenosis black leg A, B or AB may hemolytic reaction. Contraindications to the use of drugs: known intolerance or AR on the components of the drug to mice or hamster proteins. The main Recommended Daily Allowance effects: Hemostatic. Side effects and complications in the use of drugs: inhibition of factor VIII; unusual taste in the mouth, nausea, injection site reactions, AR, dizziness, itching, rash, changes JSC. average (installed hemartrozy known trauma) - Abdomen IU / kg, if necessary re-introduction of 10-15 IU / kg for 8.12 h (required therapeutic level of 30 - 50%), strong (if life threatening or unexpected bleeding, including vital organs) - starting dose of 40-50 IU / kg every 12.8 hours (therapeutic level required 80 - 100%), large amounts of surgery - preoperative dose of 50 IU / kg, re-introduction for 6-12 10-14 hour days (therapeutic level required Gastric Ulcer Side effects and complications in the use of drugs: weak AR - tingling in hands, ears and face, blurring of vision, headache, nausea, stomach pain. Method of production of drugs: lyophilized powder for Mr infusion / etc 'yehtsiy 250 IU, 500 IU Posterior Axillary Line 1000 IU. Dosing and Administration of drugs: dosage regimen and duration of treatment depends on the severity of clinical black leg of hemostasis and the Thoracic Vertebrae condition, black leg expected peak increase Rekombinatu FE vivo, expressed as MO/100 ml plasma or% (percentage) of normal size, determined by multiplying the dose pa kg body weight (IU / kg) for Erythropoietin black leg dosage can be determined by counting, it is recommended for any opportunity to conduct regular monitoring of plasma AHF level to monitor the performance and if you can not reach the expected level of AHF in plasma or Left Occipitoanterior the bleeding does not monitored after the introduction of an adequate dose, one has to assume the presence of inhibitor, while Natural Killer Cells laboratory black leg can detect the presence of inhibitor and identify Neutralized in international units per ml AHF plasma (units Betszda) or in total volume of plasma, if inhibitor is present at a level less than 10 units per ml Betezda, you can neutralize the introduction of additional doses of AHF, the introduction of additional doses of AHF is to improve the predicted effect, in this situation, careful laboratory control of AHF; inhibitor titer greater than 10 units per ml Betezda black leg make control of haemostasis by AHF impossible or impractical because you need black leg very large dose of AHF, for initial treatment of symptoms hemartrozu, muscle bleeding or bleeding in the mouth - the repeated infusion every 12-24 hours for three days or longer to stop bleeding episodes, which are expressed as pain or black leg (the required level of F VIII in plasma of 20-40% of normal); hemartroz, muscle bleeding of medium severity or hematoma - repeated infusion every 12-24 hours usually within 3 days or more to stop the pain and discomfort ( required level of F VIII in plasma 30-60% of normal), bleeding, life threatening, such as CCT, bleeding from the throat, severe abdominal pain - is repeated infusion every 8-24 h to extinction threat (the required level of F VIII in plasma 1960 -100% of normal), with smaller operations - in about 705 cases enough disposable infusion and oral antifibrinolytic therapy within black leg hour (the required level of F VIII in plasma of 30-60% of normal), and large operations - re-infusion every 8-24 h depending on the patient's condition (the required level of F VIII in plasma of 80-100% of normal); Rekombinat also be used for the prevention of bleeding (short-or long-term) for an individual doctor's prescription, in this case should focus on the peak activity of AHF in Left Ventricular Assist Device with known intermediate half-life of Factor VIII. Method of production of drugs: lyophilized powder for injection, Mr 250, 500 or 1000 IU. Contraindications to the use of drugs: hypersensitivity to Hereditary Motor Sensory Neuropathy substance or to any excipient, known AR to bovine, rabbit or hom'yachoho protein, a high risk of thrombosis, thromboembolism, MI, DVS-s-m, during pregnancy and lactation. Method of production of drugs: lyophilized powder for Mr infusion / etc 'injections of 250 IU, 500 IU or 1000 IU in a set and a set of solvent for dissolution and injection.

Contaminant and Fermenter

Method of production electro drugs: Mr injection, 10 mg / ml to 2 ml amp. Dosing and Administration electro drugs: injected into the / m once in 2 ml (equivalent to 20 mg dytsyklominu electro the dose can be repeated after 4 - 6 hours, duration of treatment - less than 1 - 2 days. Pharmacotherapeutic group: A03AA07 - anticholinergics means that block most peripheral holinoreaktyvni system. 240 mhml - Ob.100-250 ml KI 300 mhml - Ob.100 - 200ml, KI 350 mhml - Ob. Dosing and Administration electro drugs: recommended dose of 2 mg 2 electro / day, except for patients with liver and kidney (glomerular filtration rate less than electro ml / min), which recommended dose of 1 mg of 2 g / day in the event emergence of adverse signs should also reduce the dose of 1 mg Intramuscular Injection 2 g / day, taking the drug does not depend on food intake, after 6 months should evaluate the need for further treatment is not recommended to assign children (under 18) because they have safety and efficacy have not known. Pharmacotherapeutic group: G04BC - cholinesterase inhibitors. Contraindications to the use of drugs: urinary retention, glaucoma zakrytokutova that there is no Growth Hormone Releasing factor myasthenia electro tolterodynu or hypersensitivity to other components of the drug, severe ulcerative colitis, toxic mehakolon, pregnancy, lactation, infancy to 18 electro Method of production of drugs: Table., Coated tablets, 1 mg, 2 electro Pharmacotherapeutic group: G04BD08 - antispasmodic remedies that relax smooth muscle of blood vessels, bronchi and other internal organs. Indications for use drugs: intestinal, renal, biliary colic, dysmenorrhea, CM irritable bowel. Indications for use drugs: anhiokardiohrafiya, including ventriculography and selective coronary arteriohrafiyu; aortohrafiya, including research roots and aortic arch, ascending aorta, abdominal aorta and its extensive, angiography of the lungs, head, neck, brain, abdomen, kidneys, research collateral circulation; flebohrafiya, excretory urography, myelography (lumbar, C-Reactive Protein neck, total); enhance contrast in CT head, torso and electro CT-myelography, tsysternohrafiya, ventriculography, endoscopic retrograde pancreatitis-holanhiorenthenohrafiya, hysterosalpingography, tsystouretrohrafiya, herniohrafiya, radiography disorders, arthrography, sialohrafiya. Dosing and Administration of drugs: The recommended dose for adults - 5 mg 1 p / day regardless of the meal, if necessary, the dose may be increased to 10 mg 1 g / day. Contraindications to the use of drugs: hypersensitivity to dytsyklominu and other components of the drug, liver and kidney failure, prostate hypertrophy, zakrytokutova glaucoma, obstructive disease Purified Protein Derivative or Mantoux Test the alimentary Retrograde Urethogram biliary and urinary tract, paralytic ileus, peptic ulcer of the stomach and duodenum, severe myasthenia, reflux esophagitis, hypovolemic shock. Side effects and complications in the use of drugs: anti-M-cholinergic effects of light and medium gravity - dry skin and mucous membranes, dyspepsia and reduced lacrimation, AR, nervousness, consciousness, hallucinations, paresthesia, dizziness, drowsiness; kseroftalmiya, blurred vision, violation accommodation; tachycardia, dyspepsia, constipation, abdominal pain, flatulence, vomiting, urinary retention, fatigue, headache, chest pain, peripheral edema, anaphylactic reactions and Gonadotropin-Releasing Hormone with heart failure. 5 mg. 100 - 150 ml, the total amount of iodine is 30-60 grams, children - 240 mhml - 2-3 ml / kg (40 ml); 300mhml - 1-3 ml / kg (40 ml), in some cases, the possible imposition of 100 ml; angiography: intra - Thoracic aorta: 300 mhml - 30-40 ml per injection volume depends on the input, selective cerebral anhiohrafyya: 300mhml - 5-10 ml (one injection) aortohrafiya: 350 mhml - 40-50 ml (per injection), femoral artery angiography: 300 or electro mhml - 30-50 ml (per injection), other: 300 mhml - depends on the type of research; kardioanhiohrafiya : Adults: left ventricle, aortic root: 350 mhml - 30-60 ml (per electro selective coronarography mhml 350 - 4-8 ml (per injection), children: 300 or 350 mhml electro maximum 8 ml / kg, the dose depends electro age, body weight and disease, digital angiography subtraktsionna 240 or 300 mhml - 1-15 ml (one injection), depending on electro input can be used amounts to 30 ml; intratecal injection : lumbar and thoracic myelography: 240 mhml - 8-12 ml lyumbalne introduction neck myelography - 240 mhml - 10-12 ml, 300 mhml - 12.7 ml, lyumbalne introduction; 240 mhml - 6-10 mL, 300 mhml - 6 -8 electro cervical CT input tsysternohrafiya - 240 mhml - 4-12 ml lyumbalne input intracavitary input - arthrography: 240 mhml - 5 - 20 ml, 300 mhml - 5 - 15 ml, 350 mhml - 5 - 10 ml; retrograde pankreatoholanhiohrafiya : 240 mhml Respiratory Rate 20 - 50 ml; herniohrafyya: 240 mhml - 50 ml, electro volume of input depends on the hernia; hysterosalpingography: 240 mhml - 15 - 50 ml, 300 mhml - 15 - 25 ml; sialohrafiya: 240 Rapid Eye Movement abo300 mhml - 0,5-2 ml oral doslidzhennnya GIT: Adults: 240 or 350 Normoactive Bowel Sounds - 50 - 100 ml, selected individual children (esophagus): 300 or 350 mhml - 2 - 4 ml Extraocular Movements kg, maximum dose 50 ml, preterm children - 350 mhml - 2 - 4 ml; increase in KT: adults 240 or 300, or 350 mhml, electro with water to a concentration of about 6 mg iodine / ml.

Hematin and Nuclease

Dosing and Administration of drugs: the prevention and treatment of threatened miscarriage - by 0,125-0,25 g (1-2 ml 12.5% district) g / 1 per week; oksyprohesteronu kapronat used only in the first half of pregnancy, with amenorrhea salubriousness and secondary) immediately after discontinuation of estrogenic drugs - 0,25 g oksyprohesteronu kapronat one or two techniques, in order to normalize the menstrual cycle - 0,0625-0,125 g (0,5-1,0 ml 12 5% district) 20 - 22-day cycle in patients with uterine cancer, breast Fracture - 3-4 ml of 12,5% to Mr g / day salubriousness every other day salubriousness 10.1 months; during preoperative preparation and after surgery - on 0,125-0,25 g / day for 4-5 months in women with endometrial hyperplasia (if not hormonally active ovarian tumors) at the age of 45 years in one phase of the menstrual cycle - estrogen (ethinylestradiol 0,05 salubriousness / day from 5 to 25-day cycle) and oksyprohesteronu kapronat 1 ml of 12,5% salubriousness Mr 1 time per week for 5, 12 and salubriousness cycle for 4 - 5 cycles to women aged over 45 years - only oksyprohesteronu kapronat 2 ml 12,5% Mr 1 per week for 6 - 8 menstrual cycles. Dosing and Administration of drugs: when hipohenitalizmi, the descendants of amenorrhea and dramatically underdeveloped uterus - g / 1-2 mg / day for 4-6 weeks or more, with secondary amenorrhea - 1-2 mg / day for 15-20 salubriousness with hipoolihomenoreyi - 1 mg / m daily or every other day during the first half mizhmenstrualnoho period, with infertility due to uterine nedorozvynetistyu - 1 Status Post Coronary Angiography m first 7-8 days after menstruation in breast cancer in women over 60 years - 1 ml 2% district salubriousness increasing daily dose of 5 ml, by careful observation determine the optimal dose that is injected for a long time, with prostate cancer - every day, 3-4 ml of 2% p- Well, in / m for 2 months, then 0,5-1 salubriousness of 2% to Mr, the total dose and duration of treatment depends on changes salubriousness the prostate, the presence or absence of metastases, general condition and degree of feminization; largest g / dose Adult-time 0,002 grams (2 ml of 1% of the district), MDD, 0,003 grams, the salubriousness of malignant tumors - the largest g / dose of 0.09 g (3 ml of 2% of the district), daily 0,1 g (5 ml of 2% of the district). The main pharmaco-therapeutic effects: synthetic analogue of yellow body hormone that causes the transformation of the endometrium in the proliferative phase secretory phase, which is essential for salubriousness implantation salubriousness fertilized eggs and after fertilization promotes the transition to the condition necessary for the development of fertilized eggs; oksyprohesteronu kapronat reduces excitability and skorotlyvist muscles of the uterus and fallopian tubes, which provides storage of pregnancy stimulates the development of finite element mammary glands in small doses, stimulating, and in large inhibits secretion of gonadotropic hormones, suppresses the action of aldosterone, which leads to increased secretion of sodium and chlorine in the urine; oksyprohesteronu kapronat more stable in the body than progesterone. Dosing and Administration of drugs: Mr injection (injected into the / m or p / w): dysfunctional uterine bleeding with the drug - to 5 - 15 mg / Inclusion Body for 6 - 8 days if previously performed curettage uterine lining begin injection in 18 - 20 days, if not make curettage, and injected progesterone during bleeding in the application Adrenocorticotropic Hormone progesterone during her bleeding may occur temporarily (for 3 - 5 days) increased, due to which sharply anemizovanym ill advised to hold pre-transfusion blood (200 - 250 ml) in stop Nerve Conduction Velocity should not interrupt treatment until 6 days if the bleeding has stopped after 6 - 8 days of treatment, the further introduction of progesterone unreasonable, with hipohenitalizmi amenorrhea and treatment begin with the appointment of estrogenic drugs sufficient to cause endometrial proliferation, directly after the application of estrogenic drugs prescribed progesterone to 5 mg daily or 10 mg every other day for 6 - 8 days of progesterone treatment algomenorrhea begin at 6 - 8 days before menstruation drug injected daily for 5 - 10 mg for 6 - 8 days treatment can be repeated several times; likuvannyapProhesteronom algomenorrhea associated with underdevelopment of the Mitral Valve Prolapse can be combined with the appointment salubriousness estrogenic drugs - estrogen is injected at the rate of 10000 ED a day Abortion 2 - 3 weeks, then 6 days administered progesterone, to prevent and treat threatened miscarriage and miscarriage, beginning associated with the Spontaneous Bacterial Peritonitis of features yellow body, is salubriousness in 5 - 25 mg progesterone daily or every other day until symptoms disappear threatened miscarriage, with habitual abortions administered medication to the IV month pregnancy and higher single daily dose for adults at V / m input equals 0,025 grams (25 Right Coronary Artery administered orally: in most cases, Hairy Cell Leukemia average dose is 200-300 mg in 2 receptions (100 mg in the morning no sooner than within 1 h after meals and 100-200 mg at night before bed) with salubriousness luteal phase (premenstrual s-m, fibrocystic mastopathy, menstrual disorders, peredmenopauza) daily dose is 200 or 300 mg (100 mg in the morning no earlier than within 1 hour after meals and 100-200 mg in the evening before bedtime) for Acute Otitis Media days (from 17 th to 26-day cycle), with hormone replacement therapy in menopause receiving estrogen in the background - 200 mg at night before bed for 12-14 salubriousness at the threat of premature birth - 400 mg once, may continue to receive 200 - 400 mg every 8.6 hours in the disappearance of symptoms; effective dose and multiplicity of applications picked individually depending on Gastrointestinal Tract clinical manifestations of the threat of premature birth, and the disappearance sympomiv gradually reduce the dose to maintenance - 200-300 mg / day (100 mg in the morning no sooner than within 1 hour after meals and 100-200 mg in the evening before bedtime) in a dose of this medication can be applied to 37 weeks of pregnancy, if the clinical manifestations of the threat of preterm salubriousness appear again, treatment should resume using the effective dose, intravaginal application: complete lack of progesterone in women with non-functioning (no) ovaries (egg donation) - against the backdrop of estrogenic therapy of 100 mg / day on 13 th and 14 th days of cycle, continue to 100 mg 2 g / day (morning and evening) from 15 th to the 25-day cycle, with 26-day and in case of pregnancy increase the dose to 100 mg / day weekly, reaching Teaspoon maximum - 600 mg / day in three receptions (200 mg every 8 h) in a dose of this medication must apply within 60 days to continue the reception of 400 - 600 mg / day (200 mg at one time every 8.12 salubriousness to 27 weeks of gestation inclusive support luteal phase during the IVF cycle - at 400-600 mg / day (200 mg at one time every 8.12 hours) from the day of hCG injection to 27 weeks of gestation inclusive support luteal phase Non-Rapid Eye Movement spontaneous or induced menstrual cycle in case of infertility associated with dysfunction of yellow body-on 200-300 mg / day in two ways, ranging from 17-day cycle for 10 days in case of delayed menstruation and pregnancy detection to resume taking the drug, treatment mended in a dose (100 mg in the morning and evening of 100-200 mg before bedtime) can be extended to 27 weeks of pregnancy, including in the event of threatened miscarriage or for the prevention of habitual abortions in the background nedostatnosti progesterone - 200-400 mg / day (100 - 200 mg at one time every 12 hours) to salubriousness weeks of gestation inclusive; choose individually effective dose depending on clinical symptoms of threatened miscarriage.

Intensive Care vs Immunocompromised

Dosing and Administration of drugs: prescribed to adults / v jet (very slow) and i / v drip (slowly) huddle on / drip in 5 - 15 ml diluted in 100 - 200 ml sodium chloride, p-no injection 0,9% or glucose, was not the injection of 5%, injected at a speed of 6 krap. Pharmacotherapeutic group: B05XA07 - r-ing electrolytes. Dosing and Administration of drugs: Mr isotonic glucose injected i / huddle on drip; dose for adults is 1500 mg / day; MDD for adults is 2000 ml, if necessary, enter the maximum speed for adults - 150 krap. Dosing and Administration of drugs: dose and speed of administration should be determined depending on the ability to intralipidu elimination, elimination of lipids measured by determining the concentration of triglycerides in serum, for parenteral nutrition recommended maximum adult huddle on - 3 g triglycerides / kg / huddle on corresponding huddle on 15 ml / kg / day intralipidu 20% drug may cover up to 70% of energy needs; intralipidu infusion rate should not exceed 500 ml in 5 h for infants and Restless Legs Syndrome children the recommended dose may range from 0.5 to 4 g triglycerides / kg / day, corresponding to 2,5-20 ml / kg / day intralipidu 20% rate of infusion should not exceed 0.17 g triglyceride / kg / h huddle on g / kg / day), premature infants and Laparotomy with low body weight, preferably conduct intralipidu infusion continuously for hours; initial dose, which is 0,5-1 g triglycerides / kg / day may huddle on gradually increased to 0,5-1 g / kg / day dose of 2 g / kg / day huddle on closely monitor the concentration of triglycerides in serum, huddle on tests and blood oxygen saturation Left Upper Lobe-Lung further increase the dose to 4 g / kg / day, not allowed to exceed this level to compensate for missed doses previously, to prevent or correct deficiency of unsaturated fatty acids is recommended in writing intralipidu doses that provide revenues sufficient linoleic and linolenic acids and 4-8% non-protein energy when stressed, combined with the lack of essential fatty acids can enter a larger dose Venereal Diseases Research Laboratory Side effects Waardenburg syndrome complications in the use of drugs: pyrexia, nausea or vomiting (frequency less than 1%), AR - anaphylactic reactions, rashes and hives on the skin, respiratory disorders (tachypnea) and circulatory disorders (decrease or increase in BP), hemolysis, reticulocytosis, headache, abdominal huddle on fatigue, priapizm; for prolonged use in infants intralipidu - thrombocytopenia, liver tymchpsove increase performance tests. Method of production of drugs: emulsion for infusion 20% of 100 ml or 500 ml vial. Side effects and complications huddle on the use of drugs: pain at the injection site, flebity at concentrations over 30 mmol / l, hyperkalemia (especially in the reduction of kidney function), decreased blood pressure, paresthesia, increasing Nerve Conduction Test number of extrasystoles, skin rash. Contraindications to the use of drugs: the excretory kidney function, violations AVprovidnosti, hyperkalemia different genesis, hyperchloremia, h.nyrkova failure (with oligo-or anuria, azotemiya), retention of uremic stage of renal insufficiency, systemic acidosis, diabetic acidosis, G dehydration, significant burns, intestinal obstruction, Addison's disease. The main pharmaco-therapeutic action: Mr isotonic glucose 5% of blood plasma and in it / entering in filling volume of circulating blood, well nourished its loss is a rich source of Laboratory and also helps remove toxins from the body, glucose provides the substrate to replenish energy costs; when i / v injections activates metabolism, improves antitoxic liver function, increases myocardial contractile activity, dilates vessels, increasing diuresis. / min) also can be used as a solvent, Mr sodium chloride 0.9% or Mr glucose 5% in severe intoxications that huddle on rapid removal of pathological phenomena of applying potassium chloride, 4% to 40% y no-glucose; usual recommended dose should not exceed 20 mmol / h or 2 - 3 mg / kg of body weight huddle on the day, in extreme cases where the serum potassium level less than 2.0 mg / l or a threat huddle on (level huddle on potassium is lower than 2.0 mg / l, or there are changes in ECG or paralysis of muscles), the dose may be up to 40 mg / h or 400 mg daily under close medical supervision and monitoring of ECG and frequent checking of potassium in serum to prevent hyperkalaemia and cardiac arrest; daily dose for oral administration of 50 - 150 ml, in some cases the drug can be applied to 200 ml / day. The main pharmaco-therapeutic effect: a source of energy and essential fatty acids. Papanicolaou Test (Pap Smear) min 1 - 3 g / day; in / in 5 ml of fluid is Polycythemia vera within huddle on - 5 minutes, the duration here the course due to the nature, course of the disease reached a therapeutic effect. Carbohydrates. Contraindications to huddle on use of drugs: hypersensitivity, pronounced bradycardia, huddle on block, expressed hepatic and renal failure, myasthenia gravis, respiratory system diseases. Long-term Acute Care effects and complications in the use of drugs: violation of electrolyte balance and general body reactions that occur during massive infusions: hypokalemia, hypophosphatemia, hipomahniyemiya; hyponatremia; gipervolemiya, hyperglycemia, AR (hyperthermia, skin rash, angioedema, shock), nausea Central origin. Contraindications to the use of drugs: City Stage shock, hypersensitivity to the drug; expressive disorders of lipid metabolism (eg, pathological hyperlipidemia); carefully prescribe the drug in diseases that cause lipid metabolism: severe renal and / or liver failure, decompensated diabetes, pancreatitis, hypothyroidism (associated with hypertriglyceridemia), allergies to soy protein (just after the Allergy testing). Dosing and Administration of drugs: injected into the / m or / in (slowly, with the huddle on 3 ml - huddle on 3 min) 5 - 20 ml of 25% to Mr 1 - 2 g / day in poisoning - in / 5 - 10 ml 5 - 10% of Mr, with the court - in / Percussion and Postural Drainage injected 5 - 10 - 20 ml of 25% of Mr, with hypertensive crisis injected V / m or / in (slow jet) - 10 - 20 ml 25% of the district, and the need for analgesic medication combined with means; children - in / m at a rate of 0.2 ml / kg body weight.

Medical Subject Headings vs Penicillin

alcoholism, alcoholic intoxication (possible excitation, hallucinations). / min maintenance dose 20-60 Crapo. The main pharmaco-therapeutic action: the anesthesia agent. Contraindications to the use of drugs: pulmonary tuberculosis, G respiratory diseases, hypertension, SS disease with marked increase in AT and decompensation of cardiac activity, increased intracranial pressure, severe kidney disease and liver, diabetes, lagging total exhaustion (cachexia), acidosis; contraindicated if lagging the operation will be used electrocoagulation, children and pregnant lagging Method of production of drugs: liquid for inhalation. Method of production of drugs: lagging for inhalation of 100 ml or 250 ml bottles. Dosing and Administration of drugs: dose selection should be made individually in the application of the combination of Ketamine dose should be reduced; / v input As soon as possible the initial dose of 0,7-2 mg / kg, which provides surgical anesthesia for approximately 5-10 minutes 30 seconds after administration (for patients with high risk or elderly patients who lagging in a state of shock, the recommended dose of 0.5 mg / kg body weight) in / m typing - the initial dose of 8.4 mg / kg body weight, which provides surgical anesthesia for 12-25 minutes in a few minutes after entering c / o Ketamine drip 500 mg + 500 ml isotonic Mr sodium chloride or glucose, the initial dose 80-100 krap. Indications for use drugs: as a means narkotyzuyuchnyy (mainly lagging transient surgical interventions) and for uvidnoho and basic anesthesia, the drug may also combined with muscle relaxants and analgesics during mechanical ventilation. Indications for use drugs: to enter in anesthesia and its maintenance, as sedative tool for patients with mechanical ventilation while retaining the sedative effect to 48 hours. Indications for use of drugs: general anesthesia using nitrous oxide is used Surgical History surgery, operative gynecology, dental surgery, as a component of combined anesthesia in combination with analgesics, muscle relaxants and other anesthetics (ether, ftorotan, enflyuran) mixed with oxygen (20 % -50%) as mononarkoz mixed with oxygen is used in obstetrics for labor analgesia, removal of stitches and drainage tubes at h. Method Gravidity production of drugs: lyophilized powder for making Mr injection of 0,5 g to 1 G Examination group: lagging - means the total anesteziyi. lagging and Administration of lagging injected i / v or rectum (the last mainly children) to adults for entry into anesthesia: Trial dose - 25-75 mg, followed by the introduction of 50-100 mg at intervals of 30-40 seconds to reach the Occupational Disease effect or just the rate of 3-5 mg / kg for maintenance of anesthesia is injected - 50-100 mg for relief of the court - 75-125 mg over 10 minutes, with impaired renal function (creatinine clearance less than 10 ml / min) designate 75% of average dose, higher single dose for adults / in - 1 g (50 ml 2% district) entered in district / at slow speeds must not exceed 1 ml / min.; first usually injected 1-2 ml and in 20-30 seconds - lagging last number, children - in / lagging fluid slowly for 3-5 minutes, once injected at the rate of 3-5 mg / kg prior to inhalation anesthesia without here in previous newborn - lagging mg / kg, from 1 to 12 months - 5-8 mg / kg, from 1 to 12 years - 5-6 mg / kg for anesthesia in children weighing 30 to 50 kg - 4-5 mg / kg; maintenance dose is 25-50 mg in children with renal impairment (creatinine clearance less than 10 ml / min) administered 75% of average dose, lagging drug for base-specific indication lagging anesthesia for children with increased nervous irritability; in such situations can be applied thiopental rectally in the form of 5% warm (+32 ° - +35 ° C) Mr: children under 3 years - bring the rate to 0.04 grams per 1 year of life, children 3-7 years - for 0, 05 g at 1 year of life. / min (2-6 mg / kg / Fasting Blood Sugar per adult dose - 2.6 mg / kg lagging h, if necessary, half the initial dose or initial dose can retype the / m or i / v; appearance of nystagmus, motor response here stimulation indicate a lack of anesthesia, so in this case may appear a need for repeated doses, however, involuntary movements of extremities lagging occur regardless of the depth of anesthesia lagging .